Publikasi

Al Azzam, K. M. (2023). SwissADME and pkCSM Webservers Predictors: an integrated Online Platform for Accurate and Comprehensive Predictions for In Silico ADME/T Properties of Artemisinin and its Derivatives. Kompleksnoe Ispolzovanie Mineralnogo Syra, 325(2), 14–21. https://doi.org/10.31643/2023/6445.13

Ali, A., Cottrell, J. J., & Dunshea, F. R. (2023). Antioxidant, Alpha-Glucosidase Inhibition Activities, In Silico Molecular Docking and Pharmacokinetics Study of Phenolic Compounds from Native Australian Fruits and Spices. Antioxidants, 12(2). https://doi.org/10.3390/antiox12020254

Alwie, R. R., Mumpuni, E., Sulastri, L., & Simanjuntak, P. (2021). Aktivitas Ekstrak Etanol Daun Salam [Syzygium polyanthum (Wight) Walp.] Dan Studi In Silico Senyawa Kimia Penghambat Enzim α-Glukosidase. Jurnal Fitofarmaka Indonesia, 8(2), 36–42. https://doi.org/10.33096/jffi.v8i2.750

Amin, S., Hurry, Z. A. Z., Sumantri, T. A., & Fauzi, R. A. (2024). Studi Komputasional Senyawa Flavonoid Tanaman Obat sebagai Kandidat Agen Antidiabetik. Jurnal Ilmu Medis Indonesia, 4(1), 21–40. https://doi.org/10.35912/jimi.v4i1.4553

Anggraini, A. (2020). Manfaat Antioksidan Daun Salam Terhadap Kadar Glukosa Darah Dan Penurunan Apoptosis Neuron Di Hippocampus Otak Tikus Yang Mengalami Diabetes. Jurnal Medika Hutama. http://jurnalmedikahutama.com

Arundita, S., Kurniawan, F., Ismed, F., Rita, R. S., & Putra, D. P. (2020). In vitro alpha glucosidase activity of uncaria gambir roxb. And syzygium polyanthum (wight) walp. From West Sumatra, Indonesia. Open Access Macedonian Journal of Medical Sciences, 8(A), 810–817. https://doi.org/10.3889/oamjms.2020.4298

Avrahami, D., Wang, Y. J., Schug, J., Feleke, E., Gao, L., Liu, C., Naji, A., Glaser, B., & Kaestner, K. H. (2020). Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D. Molecular Metabolism, 42. https://doi.org/10.1016/j.molmet.2020.101057

Azizah, S. A., & Novrianti, I. (2022). Pharmacotherapy Of Diabetic Mellitus?: A Review Review?: Farmakoterapi Diabetes Melitus. Journal Of Pharmacy and Science), 5(2), 80–91.

Babu, S., Krishnan, M., Rajagopal, P., Periyasamy, V., Veeraraghavan, V., Govindan, R., & Jayaraman, S. (2020). Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats. European Journal of Pharmacology, 873. https://doi.org/10.1016/j.ejphar.2020.173004

Benet, L. Z., Hosey, C. M., Ursu, O., & Oprea, T. I. (2016). BDDCS, the Rule of 5 and drugability. Dalam Advanced Drug Delivery Reviews (Vol. 101, hlm. 89–98). Elsevier B.V. https://doi.org/10.1016/j.addr.2016.05.007

Cahyaningsih, A. L., & Amal, S. (2019). Evaluasi Terapi Insulin pada Penderita Diabetes Mellitus Gestasional di RSUP dr. Soeradji Tirtonegoro Klaten Periode Oktober 2014-Oktober 2017. Dalam Pharmacy Department of Unida Gontor 1 Pharmasipha (Vol. 3, Nomor 2).

da Purificação, N. R. C., Garcia, V. B., Frez, F. C. V., Sehaber, C. C., Lima, K. R. D. A., de Oliveira Lima, M. F., de Carvalho Vasconcelos, R., de Araujo, A. A., de Araújo Júnior, R. F., Lacchini, S., de Oliveira, F., Perles, J. V. C. M., Zanoni, J. N., de Sousa Lopes, M. L. D., & Clebis, N. K. (2022). Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats. Biomedicine and Pharmacotherapy, 151. https://doi.org/10.1016/j.biopha.2022.113131

Daina, A., Blatter, M. C., Baillie Gerritsen, V., Palagi, P. M., Marek, D., Xenarios, I., Schwede, T., Michielin, O., & Zoete, V. (2017). Drug Design Workshop: A Web-Based Educational Tool to Introduce Computer-Aided Drug Design to the General Public. Journal of Chemical Education, 94(3), 335–344. https://doi.org/10.1021/acs.jchemed.6b00596

Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7. https://doi.org/10.1038/srep42717

Dong, J., Wang, N. N., Yao, Z. J., Zhang, L., Cheng, Y., Ouyang, D., Lu, A. P., & Cao, D. S. (2018). Admetlab: A platform for systematic ADMET evaluation based on a comprehensively collected ADMET database. Journal of Cheminformatics, 10(1). https://doi.org/10.1186/s13321-018-0283-x

Fadillah, R. N., Rahmah, S., Nurani, S., Umami, M., Islam, U., Sunan, N., & Djati Bandung, G. (2024). Uji Deteksi Senyawa Metabolit Sekunder Daun Salam(Syzygium Polyanthum) Menggunakan Metode Maserasi Dengan Perbedaan Lama Perendaman. Sains Indonesiana: Jurnal Ilmiah Nusantara, Vol.2, NO.4.

Fischer, A., Smieško, M., Sellner, M., & Lill, M. A. (2021). Decision Making in Structure-Based Drug Discovery: Visual Inspection of Docking Results. Dalam Journal of Medicinal Chemistry (Vol. 64, Nomor 5, hlm. 2489–2500). American Chemical Society. https://doi.org/10.1021/acs.jmedchem.0c02227

Forli, S., Huey, R., Pique, M. E., Sanner, M. F., Goodsell, D. S., & Olson, A. J. (2016). Computational protein-ligand docking and virtual drug screening with the AutoDock suite. Nature Protocols, 11(5), 905–919. https://doi.org/10.1038/nprot.2016.051

Gangadhariah, M. H., Dieckmann, B. W., Lantier, L., Kang, L., Wasserman, D. H., Chiusa, M., Caskey, C. F., Dickerson, J., Luo, P., Gamboa, J. L., Capdevila, J. H., Imig, J. D., Yu, C., Pozzi, A., & Luther, J. M. (2017). Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. Diabetologia, 60(6), 1066–1075. https://doi.org/10.1007/s00125-017-4260-0

Ifaya, M., Ridwan, B. A., Laugi, P. S., Utami, A. P., & Abdurrahman, S. (2025). Antidiabetic Activity of Ethyl Acetate Compounds from Gayam (Inocarpus fagiferus): In Silico and In Vivo Studies. Indonesian Journal of Pharmaceutical Science and Technology, 12(3), 280–288. https://doi.org/10.24198/ijpst.v12i3.58070

Ismail, A., & Ahmad, W. A. N. W. (2019). Syzygium polyanthum (Wight) walp: A Potential Phytomedicine. Pharmacognosy Journal, 11(2), 429–439. https://doi.org/10.5530/pj.2019.11.67

Lestari, D. A., Ramadhan, R., Phuwapraisirisan, P., Firdaus, Y. H. F., Kurnia, I. T., Hariyanto, N. A., Suhartini, S., Abdulgani, N., Fariha, N. M., Phontree, K., Saibun, S., & Pratiwi, D. R. (2025). Phytochemicals, Antidiabetic, and Antioxidant Activities of Syzygium polyanthum Achieved by GC-MS Analysis, α-Glucosidase Inhibition and Kinetic Mechanism along with a Free Radicals Scavenging Activities. Moroccan Journal of Chemistry, 13(1), 34–56. https://doi.org/10.48317/IMIST.PRSM/morjchem-v13i1.45267

Maulana, L. H., Noor Prasetyo, R., Prayogi, S., Studi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban, P., & Raya Pagojengan Km, J. (2023). Uji Aktivitas Antioksidan Syzygium Polyanthum dan Terminalia Catappa L. Secara In Vitro Dan In Silico. Jurnal Ilmiah Farmasi, 12(3), 393–405.

Mujawah, A., Rauf, A., Bawazeer, S., Wadood, A., Hemeg, H. A., & Bawazeer, S. (2023). Isolation, Structural Elucidation, In Vitro Anti-α-Glucosidase, Anti-β-Secretase, and In Silico Studies of Bioactive Compound Isolated from Syzygium cumini L. Processes, 11(3). https://doi.org/10.3390/pr11030880

Najib, A., Olli, A. T., & Puspitasari, Y. (2025). Optimasi Ekstrak Daun Salam (Syzygium Polyanthum) Menggunakan Metode Konvensional dan Green Extraction Serta Profil Kimia dan Potensi Antioksidannya. Jurnal Mandala Pharmacon Indonesia, 11(1), 55–65. https://doi.org/10.35311/jmpi.v11i1.717

Nugraha, A. S., Kintoko, K., Putri, C. P. Z. S., Az-Zahra, F., Firli, L. N., Rani, D. M., Purnomo, Y. D., Nguyen, P. T. V., Puspitasari, R. M., Hartati, T., Triatmoko, B., Pratama, A. N. W., Wahyuni, D. S. C., Muliasari, H., Keller, P. A., & Wangchuk, P. (2025). Antidiabetic medicinal plants of Indonesia: their in silico, in vitro, in vivo and clinical trial studies. Phytochemistry Reviews. https://doi.org/10.1007/s11101-025-10173-y

Nur, A. V., Waznah, U., Mugiyanto, E., & Pambudi, D. B. (2024). Molecular Docking Metabolit Sekunder Bawang Putih (Allium Sativum) sebagai Antikanker Payudara: Pendekatan In-Silico. Journal of Intgrative Natural Science 2024, 1(1), 29–37. https://ejournal.unsika.ac.id/index.php/JoINS

Nurlely, Putra, A. M. P., Nurrochmad, A., Widyarini, S., & Fakhrudin, N. (2024). Extraction, phytochemicals, bioactivities, and toxicity of Syzygium polyanthum: A comprehensive review. Journal of Herbmed Pharmacology, 13(3), 366–380. https://doi.org/10.34172/jhp.2024.51454

Orlandella, R. M., Turbitt, W. J., Gibson, J. T., Boi, S. K., Li, P., Smith, D. L., & Norian, L. A. (2020). The antidiabetic agent acarbose improves anti-PD-1 and rapamycin efficacy in preclinical renal cancer. Cancers, 12(10), 1–19. https://doi.org/10.3390/cancers12102872

Pagadala, N. S., Syed, K., & Tuszynski, J. (2017). Software for molecular docking: a review. Dalam Biophysical Reviews (Vol. 9, Nomor 2, hlm. 91–102). Springer Verlag. https://doi.org/10.1007/s12551-016-0247-1

Petersen, M. C., & Shulman, G. I. (2018). Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev, 98, 2133–2223. https://doi.org/10.1152/physrev

Pinzi, L., & Rastelli, G. (2019). Molecular docking: Shifting paradigms in drug discovery. Dalam International Journal of Molecular Sciences (Vol. 20, Nomor 18). MDPI AG. https://doi.org/10.3390/ijms20184331

Pires, D. E. V., Blundell, T. L., & Ascher, D. B. (2015). pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. Journal of Medicinal Chemistry, 58(9), 4066–4072. https://doi.org/10.1021/acs.jmedchem.5b00104

Ponnulakshmi, R., Shyamaladevi, B., Vijayalakshmi, P., & Selvaraj, J. (2019). In silico and in vivo analysis to identify the antidiabetic activity of beta sitosterol in adipose tissue of high fat diet and sucrose induced type-2 diabetic experimental rats. Toxicology Mechanisms and Methods, 29(4), 276–290. https://doi.org/10.1080/15376516.2018.1545815

Pop-Busui, R., Boulton, A. J. M., Feldman, E. L., Bril, V., Freeman, R., Malik, R. A., Sosenko, J. M., & Ziegler, D. (2017). Diabetic neuropathy: A position statement by the American diabetes association. Diabetes Care, 40(1), 136–154. https://doi.org/10.2337/dc16-2042

Rahim, E. N. A. A., Ismail, A., Omar, M. N., Rahmat, U. N., & Nizam Wan Ahmad, W. A. (2018). GC-MS analysis of phytochemical compounds in syzygium polyanthum leaves extracted using ultrasound-assisted method. Pharmacognosy Journal, 10(1), 110–119. https://doi.org/10.5530/pj.2018.1.20

Reddy, K. A., Ashma, M., Bai, S. A., Jyothi, V., & Jyostna, T. S. (2019). Molecular Properties Prediction of Phenothiazine Derivatives by Using Swiss ADME, PkCSM, Lazar and Protox. World J Pharm Sci, 7(11), 65–71. http://www.wjpsonline.org/

Riyaphan, J., Pham, D.-C., Leong, M. K., & Weng, C.-F. (2021). biomolecules In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes. MDPI, 11, 1877. https://doi.org/10.3390/biom

Rochmat, A., Aditya, G., Kusmayanti, N., Kustiningsih, I., Hariri, A., & Rezaldi, F. (2022). Invitro Activity and Docking Approach In Silico Leaf Extract Syzygium polyanthum (Wight) Walp. as a Salmonella typhi Inhibitor. Trends in Sciences, 19(16). https://doi.org/10.48048/tis.2022.5654

Samsuri, A., Hermawan, F., Zikri, A. T., Vifta, R. L., & Puspitasari, A. D. (2025). Artificial Intelligence-Aided In Silico Screening of Syzygium polyanthum Phytochemicals for Antidiabetic Drug Discovery Using ACO (Ant Colony Optimization) Algorithm. Jurnal Masyarakat Informatika, 16(2), 184–198. https://doi.org/10.14710/jmasif.16.2.73574

Shen, Y., Qin, X., & Ren, L. (2011, November 23). RCSB PDB - 3TOP: Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose. Protein and Cell. https://www.rcsb.org/structure/3TOP

Simson, I. L., & Basuki, M. (2019). Uji Aktifitas Fraksi Daun Salam Terhadap Kadar Glukosa Darah Tikus Putih Jantan  Hiperkolesteroemia Diabetes. Farmakologika Jurnal Farmasi, (2), p.

Sulastri, L., Zulfadhli, M., Alwie, R. R., Ramani, S., Prasetiyo, A., & Simanjuntak, V. S. (2024). Aktivitas Penghambatan Enzim α-Glukosidase Senyawa β-Sitosterol dari Fraksi Etil Asetat Daun Salam [Syzygium polyanthum (Wight.) Walp. Jurnal Fitofarmaka Indonesia, 11(1), 9–16. https://doi.org/10.33096/jffi.v11i1.981

Syafriati, A. (2025). Manfaat Daun Salam Dan Daun Kemangi Dalam Sebagai Antiglikemia, Antiinflamasi Dan Antioksidan Pada Penderita Dm Tipe 2. Jurnal kesehatan dan pembangunan, 15(1).

Tukiran, T., Setiawan, A. R., Constaty, I. C., & Safitri, F. N. (2023). Tropical Journal of Natural Product Research The Potency of Java Apple (Syzygium samarangense) AS α-Glucosidase and α-Amylase Inhibitor: An In-Silico Approach. Trop J Nat Prod Res, 7(10), 4199–4124. https://doi.org/10.26538/tjnpr/v7i10.13

Vaitaitis, G. M., Olmstead, M. H., Waid, D. M., Carter, J. R., & Wagner, D. H. (2019). CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor. Reply to Pagni PP, Wolf A, Lo Conte M et al [letter]. Dalam Diabetologia (Vol. 62, Nomor 9, hlm. 1730–1731). Springer Verlag. https://doi.org/10.1007/s00125-019-4945-7

Vamathevan, J., Clark, D., Czodrowski, P., Dunham, I., Ferran, E., Lee, G., Li, B., Madabhushi, A., Shah, P., Spitzer, M., & Zhao, S. (2019). Applications of machine learning in drug discovery and development. Dalam Nature Reviews Drug Discovery (Vol. 18, Nomor 6, hlm. 463–477). Nature Publishing Group. https://doi.org/10.1038/s41573-019-0024-5

Widyawati, T., Yusoff, N. A., Bello, I., Asmawi, M. Z., & Ahmad, M. (2022). Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of Syzygium polyanthum (Wight.)’s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model. Molecules, 27(20). https://doi.org/10.3390/molecules27206814

Williams, L. K., Maurus, R., & Brayer, G. D. (2008, Maret 25). RCSB PDB - 2QV4: Human pancreatic alpha-amylase complexed with nitrite and acarbose. Worldwide Protein Data Bank. https://www.rcsb.org/structure/2QV4

Yuningtyas, S., Alfarabi, M., Lestari, Y., & Noviardi, H. (2024). The In Vitro and In Silico Study of α-glucosidase Inhibition by Kombucha Derived from Syzygium polyanthum (Wight) Walp. Leaves. HAYATI Journal of Biosciences, 31(5), 951–963. https://doi.org/10.4308/hjb.31.5.951-963

Zulcafli, A. S., Lim, C., Ling, A. P., Chye, S., & Koh, R. (2020). Antidiabetic Potential of Syzygium sp.: An Overview. Yale Journal Of Biology And Medicine, 93, 307–325.