Publikasi

DAFTAR PUSTAKA

Aeni, Q., Aini, S. R., & Surya Pratama, I. (2022). Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr). *Sasambo Journal of Pharmacy, 3*(1). https://doi.org/10.29303/sjp.v6i1.264

Ahmed, E. M. (2015). Hydrogel: Preparation, characterization, and applications: A review. *Journal of Advanced Research, 6*(2), 105–121. https://doi.org/10.1016/j.jare.2013.07.006

Anisah Putri Yuana Sari, P. T. C. H., Marshanda Nikita, A. M. A. F., Fajrina Rizqi Riyadi, & Ihsanti Dwi Rahayu. (2024). Formulation and characteristics of hydrogel patch containing pineapple peel (Ananas comosus L.) ethanol extract. *Media Farmasi Indonesia, 19*(2), 156–165. https://doi.org/10.53359/mfi.v19i2.296

Aulia Firdaus Syazidan, Emmidia Djonaedi, & Rachmah Nanda Kartika. (2025). Pengaruh konsentrasi NaOH terhadap kadar air kertas berbahan dasar daun mahkota nanas. *Jurnal Riset Rumpun Ilmu Teknik, 4*(2), 254–263. https://doi.org/10.55606/jurritek.v4i2.5624

Bjarnason, I., Scarpignato, C., Holmgren, E., Olszewski, M., Rainsford, K. D., & Lanas, A. (2018). Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs. *Gastroenterology, 154*(3), 500–514. https://doi.org/10.1053/j.gastro.2017.10.049

Brito, T. B. N., Koifman, A. B., Antonio, E. M., Carvalho, M. G. O., Cardoso, F. S. N., Bicas, J. L., Fai, A. E. C., & Ferreira, M. S. L. (2025). Turning pineapple crown waste into value: Formulation and analysis of an instant powder beverage. *Food Science and Nutrition, 13*(11). https://doi.org/10.1002/fsn3.71220

Davis, C. M., Liu, X., & Alkayed, N. J. (2017). Cytochrome P450 eicosanoids in cerebrovascular function and disease. *Physiology & Behavior, 176*(1), 139–148. https://doi.org/10.1016/j.pharmthera.2017.05.004.Cytochrome

Chain, S., Technology, P., Control, Q., Chief, E. I., Purwandari, U., Board, E., Supartono, W., Mada, U. G., Murkovic, M., Rardniyom, C., Fuad, M., Mu, F., Hidayat, K., Indarto, C., Editor, M., Firmansyah, R. A., Editor, A., Efendi, M., Iswanto, H., & Istighfarin, S. (2023). *AGROINTEK: Jurnal Teknologi Industri Pertanian, 15*(3), 845–853.

Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammation-associated diseases in organs. *Oncotarget, 9*(6). https://www.impactjournals.com/oncotarget/

Chousterman, B. G., Swirski, F. K., & Weber, G. F. (2017). Cytokine storm and sepsis disease pathogenesis. *Seminars in Immunopathology, 39*(5), 517–528. https://doi.org/10.1007/s00281-017-0639-8

Dayanti, E., Rachma, F. A., Saptawati, T., & Ovikariani, O. (2023). Penetapan parameter spesifik dan non spesifik ekstrak etanol biji buah trembesi (Samanea saman). *BENZENA Pharmaceutical Scientific Journal, 1*(2). https://doi.org/10.31941/benzena.v1i2.2390

Dwi Dominica, D. H. (2019). Formulasi dan evaluasi sediaan lotion dari ekstrak daun lengkeng (Dimocarpus longan) sebagai antioksidan. *6*(1).

Gonzáles, M., & González, A. A. (2019). La inflamación desde una perspectiva inmunológica: desafío a la Medicina en el siglo XXI. *Revista Habanera de Ciencias Médicas, 6*(5), 1–15. http://scielo.sld.cu/scielo.php?pid=S1729-519X2008000300003&script=sci_arttext

Gupta, A., & Chaphalkar, S. R. (2016). Terpenoids from three medicinal plants and their potential anti-inflammatory and immunosuppressive activity on human whole blood and peripheral blood. *Asian Journal of Ethnopharmacology and Medicinal Foods, 2*(1), 13–17.

Hariri, A. M., Saraswati, K. D., Suskandini Ratih Dirmawati, & Fitriana, Y. (2016). *Jurnal Agrotek Tropika, 12*(2), 259–269.

Harliatika, Y. (2021). Formulation and evaluation of hydrogel from agarwood leaf (Aquilaria malacensis Lamk.) ethanol extract with Carbopol 940 and HPMC K4M combination. *Journal of Pharmacy and Science, 6*(1).

Hurler, J., Engesland, A., Poorahmary Kermany, B., & Škalko-Basnet, N. (2012). Improved texture analysis for hydrogel characterization: Gel cohesiveness, adhesiveness, and hardness. *Journal of Applied Polymer Science, 125*(1), 180–188. https://doi.org/10.1002/app.35414

Ikhwan Habibi, A., Arizal Firmansyah, R., Mukhlishoh Setyawati, S., & Hamka Kampus Ngaliyan Semarang, J. I. (2018). Skrining fitokimia ekstrak n-heksan korteks batang salam (Syzygium polyanthum). *Indonesian Journal of Chemical Science, 7*(1). http://journal.unnes.ac.id/sju/index.php/ijcs

Irianto, I. D. K., Purwanto, P., & Mardan, M. T. (2020). Aktivitas antibakteri dan uji sifat fisik sediaan gel dekokta sirih hijau (Piper betle L.) sebagai alternatif pengobatan mastitis sapi. *Majalah Farmaseutik, 16*(2), 202. https://doi.org/10.22146/farmaseutik.v16i2.53793

Jesch, E. D., & Carr, T. P. (2017). Food ingredients that inhibit cholesterol absorption. *Preventive Nutrition and Food Science, 22*(2), 67–80. https://doi.org/10.3746/pnf.2017.22.2.67

Khikmawati, N. (2019). *Uji aktivitas antibakteri ekstrak etanol kulit buah nanas (Ananas comosus (L.) Merr) dalam formulasi sediaan sabun cair terhadap bakteri Staphylococcus aureus*.

Kumaunang, M., & Kamu, V. (2011). Aktivitas enzim bromelin dari ekstrak kulit nenas (Ananas comosus).

Larasati, A. (2021). Uji aktivitas antiinflamasi ekstrak biji petai cina (Leucaena leucocephala L.) pada inflamasi kaki tikus galur Wistar. *3*(1), 1689–1699. http://journal.unilak.ac.id/index.php/JIEB/article/view/3845

Lawal, D. (2014). Medicinal, pharmacological and phytochemical potentials of Annona comosus linn. peel: A review. *Bayero Journal of Pure and Applied Sciences, 6*(1), 101. https://doi.org/10.4314/bajopas.v6i1.21

Lei, W., Wang, S., Xu, N., Chen, Y., Wu, G., Zhang, A., Chen, X., Tong, Y., & Qian, W. (2020). Enhancing therapeutic efficacy of oncolytic vaccinia virus armed with Beclin-1, an autophagic gene in leukemia and myeloma. *Biomedicine and Pharmacotherapy, 125*, 110030. https://doi.org/10.1016/j.biopha.2020.110030

Maslahah, N. (2024). *Standar simplisia tanaman obat sebagai bahan sediaan herbal* (Vol. 2, No. 2). https://poltekkespim.ac.id

Muchtaromah, B., Majid, A. F., Aqila, H., Hayati, A., & Rehan, M. M. (2025). Formulation and physical evaluation of hydrogel extract combination of Centella asiatica and Moringa oleifera using Simplex Lattice Design method. *IOP Conference Series: Earth and Environmental Science, 1439*(1). https://doi.org/10.1088/1755-1315/1439/1/012034

Muhammad Tarmidzi, F., Kresna Maharsih, I., Raihatul Jannah, T., & Sari Wahyuni, C. (2020). Sintesis hidrogel pektin-gelatin dengan penambahan ekstrak kulit buah naga sebagai kandidat pembalut luka bakar. *Jurnal Teknik Kimia dan Lingkungan, 2020*(1), 53–60. https://www.jtkl.polinema.ac.id

Nasrudin, M. F. (2023). *Uji aktivitas sediaan hidrogel nanopartikel ekstrak daun jarak cina (Jatropha multifida L.) terhadap penyembuhan luka sayat pada kelinci (Oryctolagus cuniculus)*. *Journal of Engineering Research*.

Nawwal, N., Fadillah, A., & Fauzi, M. (2025). Variasi konsentrasi Carbomer 940-Triethanolamine (TEA) dan evaluasi pada formulasi peeling gel ekstrak kulit buah nanas (Ananas comosus). *Jurnal Kesehatan Tambusai, 6*(1), 2533–2542. https://doi.org/10.31004/jkt.v6i1.40124

Nunes, C. D. R., M., B. A., S., M. de F. P., Leandro da Cruz, L., M., de S. P., L., P. de M., Vieira, I. J. C., & D, B. de O. (2020). Plants as sources of anti-inflammatory agents. *Molecules, 25*(16), 3726.

Pavan, R., Jain, S., Shraddha, & Kumar, A. (2012). Properties and therapeutic application of bromelain: A review. *Biotechnology Research International, 2012*, 1–6. https://doi.org/10.1155/2012/976203

Perrianty, F., Berliana Yanti, N., Raihana, N., & Saputra, H. (2024). Maserasi dari ekstrak kental dari mahkota nanas (Ananas comosus (L.) Merr) sebagai agen lipbalm. *Pharmacon Journal, 2*(1). http://ojs.stikeskeluargabunda.ac.id/index.php/pharmaconjurnal

Rahayuningdyah, D. W., Lyrawati, D., Widodo, F., & Puspita, O. E. (2020). Pengembangan formula hidrogel balutan luka menggunakan kombinasi. *Pharmaceutical Journal of Indonesia, 5*(2), 117–122.

Reiza, I. A., Rijai, L., & Mahmudah, F. (2019). Skrining fitokimia ekstrak etanol kulit nanas (Ananas comosus (L.) Merr). *Proceeding of Mulawarman Pharmaceuticals Conferences, 10*, 104–108. https://doi.org/10.25026/mpc.v10i1.371

Saptarini, N., Rahayu, D., & Herawati, I. (2019). Antioxidant activity of crude bromelain of pineapple (Ananas comosus (L.) Merr) crown from Subang district, Indonesia. *Journal of Pharmacy and Bioallied Sciences, 11*(8), S551–S555. https://doi.org/10.4103/jpbs.JPBS_200_19

Sari, R., & I. D. (2014). Studi efektivitas sediaan gel antiseptik tangan ekstrak daun sirih (Piper betle Linn.).

Sari, R., Nurbaeti, S. N., & Pratiwi, L. (2016). Optimasi kombinasi Karbopol 940 dan HPMC terhadap sifat fisik gel ekstrak dan fraksi metanol daun kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design.

Selvakumar, P. M., Rajkumar, S. R. J., & MSA, M. N. (2018). Phytochemicals as a potential source for anti-microbial, anti-oxidant and wound healing: A review. *MOJ Bioorganic & Organic Chemistry, 2*(2), 61–70. https://doi.org/10.15406/mojboc.2018.02.0058

Septiani, A., Wirasti, W., Slamet, S., & Urmatul Waznah. (2021). Uji aktivitas antioksidan sediaan masker hidrogel ekstrak etanol teh hijau (Camellia sinensis) dengan metode BCB. *Seminar Nasional Kesehatan*, 2148–2156.

Setiawan, I., Lindawati, N. Y., & Amalia, B. (2022). Formulasi dan uji antiinflamasi sediaan hidrogel ekstrak jahe merah (Zingiber officinale).

Sharma, A., Kumar, L., Malhotra, M., Singh, A. P., & Singh, A. P. (2024). Ananas comosus (pineapple): A comprehensive review of its medicinal properties, phytochemical composition, and pharmacological activities. *Journal of Drug Delivery and Therapeutics, 14*(5), 148–157. https://doi.org/10.22270/jddt.v14i5.6557

Sheila Ameyfiana Habiba, Dara Pranidya Tilarso, A. E. P. P. (2022). Pengaruh konsentrasi Karbomer-940 pada sediaan emulgel minyak zaitun dan ekstrak daun kelor. *Jurnal Sains dan Kesehatan, 4*(1), 242–247.

Singh, V., & Chaubey, N. (2019). Design and evaluation of topical hydrogel formulation of aceclofenac for improved therapy. *Journal of Drug Delivery and Therapeutics, 9*(5), 118–122. https://doi.org/10.22270/jddt.v9i5.3605

Slamet, S., Anggun, B. D., & Pambudi, D. B. (2020). Uji stabilitas fisik formula sediaan gel ekstrak daun kelor (Moringa oleifera Lamk.). *Jurnal Ilmiah Kesehatan, 13*(2), 115–122. https://doi.org/10.48144/jiks.v13i2.260

Smeriglio, A., Barreca, D., Bellocco, E., & Trombetta, D. (2017). Proanthocyanidins and hydrolysable tannins: Occurrence, dietary intake and pharmacological effects. *British Journal of Pharmacology, 174*(11), 1244–1262. https://doi.org/10.1111/bph.13630

Solekhah, S., & Pambudi, D. B. (2020). Uji efektifitas antiinflamasi ekstrak etanol herba semanggi air (Marsilea crenata) pada udema telapak kaki tikus jantan galur Wistar (Rattus norvegicus). *1–5*.

Sutomo, S., Rahmawati, A., & Rizki, M. I. (2017). Standardisasi buah cabe rawit Hiyung (Capsicum frutescens L.) asal Tapin Kalimantan Selatan. *JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi dan Kesehatan, 2*(2), 245–253. https://doi.org/10.36387/jiis.v2i2.121

Taminggu, E. R., & Tahril, T. (2022). Identifikasi senyawa metabolit sekunder pada batang dan daun lamun (seagrass) di Teluk Palu. *Media Eksakta, 18*(1), 6–11. https://doi.org/10.22487/me.v18i1.1016

Thomas, N. A., Tungadi, R., Hiola, F., & S. Latif, M. (2023). Pengaruh konsentrasi Carbopol 940 sebagai gelling agent terhadap stabilitas fisik sediaan gel lidah buaya (Aloe vera). *Indonesian Journal of Pharmaceutical Education, 3*(2). https://doi.org/10.37311/ijpe.v3i2.18050

Toni Priyanto, Slamet, & M. A. (2018). Uji aktivitas appitutte fraksi n-heksan dan metanol ekstrak daun brotowali (Tinospora crispa Linn.) terhadap berat badan tikus putih betina galur Wistar (Rattus norvegicus). *3*(1), 10–27. https://medium.com/@arifwicaksanaa/pengertian-use-case-a7e576e1b6bf

Torres, D. da S., Pereira, E. C. V., Sampaio, P. A., De Souza, N. A. C., Ferraz, C. A. A., De Oliveira, A. P., Moura, C. A., Almeida, J. R. G. S., Rolim-Neto, P. J., De Oliveira-Júnior, R. G., & Rolim, L. A. (2018). Influence of extraction process on flavonoid content from Cnidoscolus quercifolius Pohl (Euphorbiaceae) and antioxidant activity. *Quimica Nova, 41*(7), 743–747. https://doi.org/10.21577/0100-4042.20170236

Uçan, B., Özbek, M., ?ahin, M., Kizilgül, M., & Çakal, E. (2017). Cyclooxygenase-2 (COX-2) gene polymorphism in patients with differentiated thyroid carcinomas in the Turkish population. *Turkish Journal of Medical Sciences, 47*(6), 1848–1853. https://doi.org/10.3906/sag-1708-49

Van Der Poll, T., Van De Veerdonk, F. L., Scicluna, B. P., & Netea, M. G. (2017). The immunopathology of sepsis and potential therapeutic targets. *Nature Reviews Immunology, 17*(7), 407–420. https://doi.org/10.1038/nri.2017.36

Virshette, S. J., Patil, M. K., & Somkuwar, A. P. (2019). A review on medicinal plants used as anti-inflammatory agents. *8*(3), 1641–1646.

Wahidah, S., Saputri, G. A. R., & Nofita, N. (2024). Formulasi dan uji stabilitas sediaan gel ekstrak etanol daun asam jawa (Tamarindus indica L.) dengan variasi gelling agent. *Jurnal Mandala Pharmacon Indonesia, 10*(2), 508–518. https://doi.org/10.35311/jmpi.v10i2.623

Wardani, K. (2022). *Optimasi berbagai humektan dalam formulasi hand and body gel ekstrak kulit nanas (Ananas comosus (L.) Merr)* [Karya tulis ilmiah].

Werawati, A., Dewi, B. S., Hasanah, U., Aulia, G., & Fairuz, A. (2024). Formulasi dan uji aktivitas antibakteri sediaan hidrogel ekstrak etanol daun kelor. *Edu Masda Journal, 8*(2).

Widianti, Z. (2017). *Efek antiinflamasi ekstrak etanol daun zaitun (Olea europaea L.) pada edema telapak kaki tikus galur Sprague-Dawley jantan yang diinduksi karagenan* [Skripsi, Universitas Islam Negeri Syarif Hidayatullah Jakarta].

Windi Fresha Qomara, Ida Musfiroh, & Rina Wijayanti. (2023). Evaluasi stabilitas dan inkompatibilitas sediaan oral liquid Windi. *8*(3).

Zeliha, K. P., Dilek, O., Ezgi, O., Halil, K., Cihan, U., & Gul, O. (2020). Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population. *Saudi Pharmaceutical Journal, 28*(2), 215–219. https://doi.org/10.1016/j.jsps.2019.11.024