Publikasi

Anonim, 2020, Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/603/2020 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Diabetes Melitus Tipe 2 Dewasa, Jakarta: Kementrian Kesehatan Republik Indonesia. 2, 1–9.

Allaoui, B. E., Benzeid, H., Zari, N., Qaiss, A. el kacem, & Bouhfid, R. (2023). Functional cellulose-based beads for drug delivery: Preparation, functionalization, and applications. Journal of Drug Delivery Science and Technology, 88, 104899.

Alshahrani, S. M., Alotaibi, H. F., & Alqarni, M. (2024). Modeling and validation of drug release kinetics using hybrid method for prediction of drug efficiency and novel formulations. Frontiers in Chemistry, 12(7), 1–12.

Atre, P., & Rizvi, S. A. A. (2025). Advances in Oral Solid Drug Delivery Systems: Quality by Design Approach in Development of Controlled Release Tablets. BioChem, 5(2), 1-7

 Azizah, A., Triyanti, D., Sahira, P., Putri, A., Lestari, R. S. D., dan Jayanudin, J. (2026). ALCHEMY Jurnal Penelitian Kimia Synthesis and Characterization of Carrageenan-Chitosan Milkfish Scales-Based. 22(1), 157–169.

 Bhadru, B., Rao, T. R., & Jadav, B. (2023). UV Spectrophotometric Method Development and Validation for Metformin Hydrochloride in Bulk and its Tablet Formulation. Chemistry Research Journal, 8(6), 10–15.

 Cahyono, B., Suzery, M., Hadiyanto, H., & Bela Pratiwi, S. (2018). Encapsulation Rutin with Chitosan-NATPP  Using Coaservation Method. Reaktor, 17(4), 215-220.

 Collado-González, M., Espinosa, Y. G., & Goycoolea, F. M. (2019). Interaction between Chitosan and Mucin: Fundamentals and applications. Biomimetics, 4(2), 1–20.

Dange, Y. D., Honmane, S. M., Bhinge, S. D., Salunkhe, V. R., & Jadge, D. R. (2017). Development and validation of uv-spectrophotometric method for estimation of metformin in bulk and tablet dosage form. Indian Journal of Pharmaceutical Education and Research, , 51(4), 109-113.

 Drzewoski, J., & Hanefeld, M. (2021). The current and potential therapeutic use of metformin—the good old drug. Pharmaceuticals, 14(2), 1–33.

 Dumitrescu, R., Mehedintu, C., Briceag, I., Purc?rea, V. L., & Hudita, D. (2015). Metformin-clinical pharmacology in PCOs. Journal of Medicine and Life, 8(2), 187-192.

 Faramarzi, B., Moggio, M., Diano, N., Portaccio, M., & Lepore, M. (2023). A Brief Review of FT-IR Spectroscopy Studies of Sphingolipids in Human Cells. Biophysica, 3(1), 158–180.

 Hariyanti, Erizal, Mustikarani, E., Lestari, I., & Lukitowati, F. (2022). In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation. Atom Indonesia, 48(1), 37-43.

 Herawati, L. W., Himawan, N. S. S., & Kusmini. (2021). Penggunaan Metformin terhadap Kejadian Efek Samping Mual Muntah pada Pasien Diabetes Melitus. Jurnal Pendidikan Tambusai, 5(3), 11328–11332.

 Heredia, N. S., Vizuete, K., Flores-Calero, M., Katherine Pazmiño, V., Pilaquinga, F., Kumar, B., & Debut, A. (2022). Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid). PLoS ONE, 17(3), 1–28.

 Jabeen, F., Zil-E-Aimen, N., Ahmad, R., Mir, S., Awwad, N. S., & Ibrahium, H. A. (2025). Carrageenan: structure, properties and applications with special emphasis on food science. RSC Advances, 15(27), 22035–22062.

 Kamenova, K., Prancheva, A., Stoyanova, S., Radeva, L., Tibi, I. P. El, Yoncheva, K., Ravutsov, M. A., Marinova, M. K., Simeonov, S. P., Mitova, S., Eneva, R., Zaharieva, M. M., Najdenski, H., & Petrov, P. D. (2024). Functional Hydrogels for Delivery of the Proteolytic Enzyme Serratiopeptidase. Gels, 10(3), 1-15.

 Kanto, K., Ito, H., Noso, S., Babaya, N., Hiromine, Y., Taketomo, Y., Toma, J., Niwano, F., Yasutake, S., Kawabata, Y., & Ikegami, H. (2018). Effects of dosage and dosing frequency on the efficacy and safety of high-dose metformin in Japanese patients with type 2 diabetes mellitus. Journal of Diabetes Investigation, 9(3), 587–593.

 Kim, E. S., Baek, Y., Yoo, H. J., Lee, J. S., & Lee, H. G. (2022). Chitosan-Tripolyphosphate Nanoparticles Prepared by Ionic Gelation Improve the Antioxidant Activities of Astaxanthin in the In Vitro and In Vivo Model. Antioxidants, 11(3), 1-12.

  Komersová, A., Svoboda, R., Skalická, B., Bartoš, M., Šnejdrová, E., Mužíková, J., & Matzick, K. (2022). Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine. Pharmaceuticals, 15(8), 1-25.

 Korsmeyer, R. W., Gurny, R., Doelker, E., Buri, P., & Peppas, N. A. (1983). Mechanisms of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics, 15(1), 25–35.

 Kotha, A. A., Ahmad, S. U., Dewan, I., Rahman, F. I., Mohamed, I. N., Reza, M. S., & Bhuiyan, M. A. (2023). Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design. Drug Design, Development and Therapy, 17, 3661-3684.

 Kumar, S., & Rathi, J. C. (2024). Design , Evaluation and Optimization of Sustained Release Metformin HCl Matrix Tablet. 12(6), 606–619.

 Kumari, M., Sekhar Ghosh, N., Kumar Singh, L., & Dubey, A. (2025). Natural and synthetic polymers: A comprehensive review of their applications in drug delivery and pharmaceutical research. International Journal of Pharmaceutical Chemistry and Analysis, 12(3), 131–144.

 Kurdi, A., Alhussaini, W., Alawaji, A., Alhudathi, A., Alharbi, R., Binsaleh, F., Alghamidi, Y., Al Bekairy, A., Alkatheri, A., Islam, I., Farh, I., Ghanem, E., & Mansour, M. (2024). Comparative performance of liquid chromatography and spectrophotometry in determining metformin hydrochloride within pharmaceutical formulations. Heliyon, 10(12), 1-13.

 Lal, J. S., Radha, D., & Devaky, K. S. (2024). Design and synthesis of chitosan/alginate/zinc oxide nanocomposite hydrogel beads as carrier for metformin hydrochloride. Journal of Molecular Structure, 1317(6), 1-12.

 Lewis, A., Williams, K., & Oroszi, T. (2024). Metformin—Pharmacokinetic and Pharmacodynamics Journey Through the Body. Pharmacology & Pharmacy, 15(12), 466–477.

Lusiana, R. A., Protoningtyas, W. P., Wijaya, A. R., Siswanta, D., Mudasir, & Santosa, S. J. (2017). Chitosan-tripoly phosphate (CS-TPP) synthesis through cross-linking process: The effect of concentration towards membrane mechanical characteristic and urea permeation. Oriental Journal of Chemistry, 33(6), 2913-2919.

Made, N., Sanjiwani, S., & Sudiarsa, W. (2021). Jurnal Emasains: Jurnal Edukasi Matematika dan Sains Analisis Gugus Fungsi Obat Sirup Batuk Dengan Fourier Transform Infrared. Jurnal Emasains: Jurnal Edukasi Matematika Dan Sains, 11(2), 339–345.

 Malektaj, H., Drozdov, A. D., & deClaville Christiansen, J. (2023). Mechanical Properties of Alginate Hydrogels Cross-Linked with Multivalent Cations. Polymers, 15(14), 1-11.

 Minamii, T., Nogami, M., & Ogawa, W. (2018). Mechanisms of metformin action: In and out of the gut. In Journal of Diabetes Investigation, 9(4), 701-703.

 Mir, A., Fletcher, W. J., Taylor, D. K., Alam, J., & Riaz, U. (2024). Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels. ACS Omega, 9(17), 18766-18776.

 Mitrevska, I., Achkoska, T., Brezovska, K., Toshev, K., Dimitrovska, A., & Ugarkovic, S. (2019). Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets. Journal of Analytical Methods in Chemistry, 1-8.

 Mukhlisatun, M., Yuanita, E., Sudirman, S., Ulfa, M., & Handayani, S. S. (2024). Sintesis dan Karakterisasi Komposit Beads Kitosan/Grafena Melalui Pengikatan Silang oleh Na3PO4. Jurnal Ilmiah Multidisipin, 2(11), 544–552.

 Nurani, L. H., Edityaningrum, C. A., Irnawati, I., Putri, A. R., Windarsih, A., Guntarti, A., & Rohman, A. (2023). Review: Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review. Indonesian Journal of Chemistry, 23(2), 542–567.

 Ishola, B., Rahaman, K. A., Razzak, S. A., Rumon, M. M. H., Shakil, M. S., & Uddin, S. (2026). Advanced mechanisms of polymer-based drug delivery systems for clinical applications. RSC Pharmaceutics, 331–360.

 Patkowska, S.P., Cichy, M., & Flieger, J. (2025). Application of Fourier Transform Infrared (FTIR) Spectroscopy in Characterization of Green Synthesized Nanoparticles. Molecules, 30(3), 1–36.

Pereira, A. de S. B. F., de Souza Lima, M. L., da Silva-Junior, A. A., dos Santos Silva, E., de Araújo Júnior, R. F., Martins, A. A., Alves, J. S. F., Oliveira, A. de S., De Santis Ferreira, L., de Araújo Costa, E. C. T., Guerra, G. C. B., de Medeiros, C. A. C. X., Brito, G. A. C., de Carvalho Leitao, R. F., & de Araújo, A. A. (2021). In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model. Pharmaceutical Biology, 59(1), 1574-1582.

 Quito, E. M. P., Ruiz-Caro, R., & Veiga, M. D. (2020). Carrageenan: Drug delivery systems and other biomedical applications. Marine Drugs, 18(11), 1-39.

 Rahmasari, K. S., & Ishartono, B. (2024). Antioxidant Release Profile from Chitosan/?-Carrageenan-based Polyelectrolyte Complex Films as Active Packaging: A Preliminary Study. In Molekul, 19(3), 443–454.

 Rahmasari, K. S., Waznah, U., Alfarizi, M. B., & Khoiriyah, N. (2021).Analisis Natrium Benzoat Pada Minuman Kemasan Di Kabupaten Pekalongan Dengan Spektrofotometri UV-Vis. Journal of Scince, Technology, and Entrepreneurship, 3(2), 70-75.

 Rahmasari, K. S., Wirasti, Maharani, V., Putri, E. A., Rahmadhani, A., Sabilla, E., & Ishartono, B. (2025). Physicochemical and Catechin Release Properties of Carboxymethyl Cellulose/κ-carrageenan’s Composite as Precursor of Active Green Packaging: A Preliminary Study. Indonesian Journal of Chemical Studies, 4(2), 52–59.

 Rahmi, S., Harahap, N. D., dan Tarigan,  R. S. P. B., (2021). Sistem Penghantaran Obat ( Drug Delivery System ), 9-35, Nuansa Fajar Cemerlang, Jakarta.

 Sembiring, B. M. (2023). Analisis Secara Simultan Kandungan Metformin HCl Dan Glibenklamid Dalam Sediaan Tablet Secara Spektorfotometri Ultraviolet. Biologi Education Science & Tecnology Journal, 6(1), 704–710.

Shadiq, Z., Ardani, M. S., Wardani, N. I., Angeline, A. Y., & Ningrum, S. S. (2025). Enkapsulasi Kurkumin dalam Matriks Beads Kitosan-Karaginan yang Tertaut-Silang dengan Glutaraldehida menggunakan Asam Laurat sebagai Pengemulsi. Sinteza, 5(2), 82–91.

 Shrivastava, A. (2018). Introduction to Plastics Engineering. In Introduction to Plastics Engineering.

 Silva, S. S., Gomes, J. M., Rodrigues, L. C., & Reis, R. L. (2020). Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications. In Marine Drugs, 18(3), 1-36.

Stavarache, C. E., Ghebaur, A., Dinescu, S., Samoil?, I., Vasile, E., Vlasceanu, G. M., Iovu, H., & Gârea, S. A. (2021). 5-aminosalicylic acid loaded chitosan-carrageenan hydrogel beads with potential application for the treatment of inflammatory bowel disease. Polymers, 13, 2537.

 Sun, M. L., Liu, F., Yan, P., Chen, W., & Wang, X. H. (2023). Effects of food on pharmacokinetics and safety of metformin hydrochloride tablets: A meta-analysis of pharmacokinetic, bioavailability, or bioequivalence studies. Heliyon, 9(7), 1-12.

 Sun, X., Liu, C., Omer, A. M., Yang, L. Y., & Ouyang, X. kun. (2019). Dual-layered pH-sensitive alginate/chitosan/kappa-carrageenan microbeads for colon-targeted release of 5-fluorouracil. International Journal of Biological Macromolecules, 132, 487-494.

 Tan, Y., Si, X., Zhong, L., Feng, X., Yang, X., Huang, M., & Wu, C. (2016). Development and validation of dissolution testings in acidic media for rabeprazole sodium delayed-release capsules. Drug Development and Industrial Pharmacy, 42(1), 133-142.

 Tom J. (2023). UV-Vis Spectroscopy: Principle, Strengths and Limitations and Applications. Technology Networks, 24(11), 1-21.

 Ways, T. M. M., Lau, W. M., & Khutoryanskiy, V. V. (2018). Chitosan and its derivatives for application in mucoadhesive drug delivery systems. Polymers, 10(3), 1-37.

 Yahoum, M. M., Toumi, S., Tahraoui, H., Lefnaoui, S., Kebir, M., Amrane, A., Assadi, A. A., Zhang, J., & Mouni, L. (2023). Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride. Micromachines, 14(3), 1-16.

 Zhang, L., Alfano, J., Race, D., & Davé, R. N. (2018). Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting. In European Journal of Pharmaceutical Sciences 117(2017), 160-169.

 Zhang, Y., Kobayashi, K., Kusumi, R., Kim, U. J., & Wada, M. (2024). Adsorption properties of cellulose beads prepared by emulsion-gelation method and subsequent oxidation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 680, 1-32.